Specifications

Functionalizedvon-Hippel-Lindauproteinligand(VHL)forPROTACresearchanddevelopment;incorporatesanE3ligaseligandplusaPEGlinkerreadyforconjugationtoatargetproteinligand.PartofarangeoffunctionalizedtoolmoleculesforPROTACR&D.

ProductInformation

Purity:                >95%MW:                  656.23Formula:              C30H45N5O7S.HClCASNumber           2097971-11-2PhysicalState:          LyophilizedwhitesolidQuantity:              5mg;10mg;25mgSolubility:             65mg/mLinDMSO;65mg/mLinwaterStorage:               Storeat-20C.

References

1.Zengerleetal(2015)SelectivesmallmoleculeinduceddegradationoftheBETbromodomainproteinBRD4.ACSChem.Biol.101770PMID:260356252.Salamietal(2017)Wastedisposal-Anattractivestrategyforcancertherapy.Science3551163PMID:28302825

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