Specifications

Derivative of Thalidomide (Cat.No. PC-1006), commonly used as a precursor to PROTACs that hijack cereblon as the E3 ubiquitin ligase component. Supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.

Product Information

Purity:                                       >98%MW:                                          332.26Formula:                                  C15H12N2O7CAS Number                           1061605-21-7Physical State:                        Lyophilized off white solidQuantity:                                  5mg; 10mg; 25mgSolubility:                                30 mg/mL in DMSOStorage:                                    Store at room temperature.

References

1. Lohbeck and Miller (2016) Practical synthesis of a phthalimide-based cereblon ligand to enable PROTAC development. Bioorg.Med.Chem.Lett. 26 5260 PMID: 27687673

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