Specifications

Background

Cell-permeable derivative of E64-C, an inhibitor of calpain and other cysteine proteases, such as papain, cathepsin B and cathepsin L^1,2. Addition to cell cultures should be done in serum-free media as esterases in serum will cleave the ethyl ester and reduce cell permeability. Typical working concentration is 0.5-10 μg/ml. Inhibits degradation of autophagic cargo inside autolysosomes³

Purity:	98.0% by HPLC
MW:	342.4
Formula:	C17H30N2O5
CAS No.	88321-09-9
Physical State:	Lyophilized white to off-white powder
Solubility:	20 mg/mL in DMSO, 10mg/mL in ethanol
Storage:	Store, as supplied, at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.

References1. EB MCGowanet al. Biochem. Biophys. Res. Commun.1989 158:4322. D Wilcox and RW MasonBiochem. J.1992 285:4953. N Mizushimaet al. Cell2010 140:313

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