Specifications

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a short alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Product Information

Purity:                 >95%MW:                      438.86Formula:              C19H22N4O6.HClPhysical State:      Lyophilized white solidQuantity:              5mg; 10mg; 25mgSolubility:             40 mg/mL in DMSO; 40 mg/mL in waterStorage:                 Store at -20C.

References

1. Winter et al (2015) Functionalized Cereblon ligand for PROTACs; incorporates an E3 ligase ligand and a linker used in PROTAC technology. Science 348 1376 PMID: 259993702. Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825

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