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商品描述
ProductDetails
| CatalogNo./Size: | GMH055F-025/25Tests GMH055F-100/100Tests | |
| Vol.per.Test: | 10μl/Test | |
| Clone: | 143-13 | |
| Isotype: | MouseIgG1 | |
| Reactivity: | Human,Notyettestedinotherspecies. | |
| Workshop: | N/A | |
| StorageBuffer: | Phosphate-bufferedsolution,pH7.4,containing0.09%sodiumazideand0.2%(w/v)BSA | |
| StorageCondition: | Storeat4�C.DONOTFREEZE.LIGHTSENSITIVEMATERIAL. | |
| Applications: | FlowCytometry | |
| ApplicationsNotes: | FACS:Use10µlfor106cells | |
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| Description: | 143-30reactswithCD55,a70kDaGPIanchoredsinglechainglycoprotein,referredtoasdecayacceleratingfactor(DAF).CD55iswidelyexpressedonhematopoieticcellsincludingerythrocytesandNKcells,aswellasonsomenon-hematopoieticcells.DAFprotectscellsfromdamagebyautologouscomplementbypreventingtheamplificationstepsofthecomplementcomponents.AdefectivePIG-AgenecanleadtoadeficiencyofGPI-likedproteinssuchasCD55andanacquiredhemolyticanemia.ThisBIOLOGicalstateiscalledparoxysmalnocturnalhemoglobinuria(PNH).LossofprotectiveproteinsonthecellsurfacemakestheredbloodcellsofPNHpatientssensitivetocomplement-mediatedlysis. | |
