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商品描述
ProductDetails
| CatalogNo./Size: | GMH040Z-025/25Tests GMH040Z-100/100Tests | |
| Vol.per.Test: | 10μl/Test | |
| Clone: | GM1CD40 | |
| Isotype: | MouseIgG2a | |
| Reactivity: | Human,Notyettestedinotherspecies. | |
| Workshop: | N/A | |
| StorageBuffer: | Phosphate-bufferedsolution,pH7.4,containing0.09%sodiumazideand0.2%(w/v)BSA | |
| StorageCondition: | Storeat4�C.DONOTFREEZE.LIGHTSENSITIVEMATERIAL. | |
| Applications: | FlowCytometry | |
| ApplicationsNotes: | FACS:Use10µlfor106cells | |
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| Description: | GM1CD40reactswithCD40(Bp50),�a�memberoftheTNFreceptorfamily�with48kDaMW.�which�isexpressed�onBlymphocytesincludingpro-Bthroughtoplasmacellsbutnotonmonocytesnorgranulocytes.CD40alsoexpressedondendriticcellsandCD34+hemopoieticcellProgenitor.CD40moleculeinvolvedinregulationofB-cellgrowth,differentiationandIsotype-switchingofIgandup-regulatesadhesionmoleculesondendriticcellsaswellaspromotescytokineproductioninmacrophagesanddendriticcells.CD40antibodieshasbeenreportedtoco-stimulateB-cellproleferationwithanti-morphorbolesters.Itmaybeanimportanttargetforcontrolofgraftrejection,Tcellsandantibody-mediated�autoimmunediseases. | |
