DESCRIPTION:

Afullyvalidated,highlyspecificrabbitpolyclonalantibodytoSerine-2814phosphorylatedRyanodineReceptor2

TheRyanodineReceptor(RyR2)isaCa²⁺channelofcardiacmusclethatplaysacentralroleinECcoupling.ThebindingofCa²⁺toRyanodineReceptor2RyR2opensthechannelandCa²⁺storedintheSRmovesthroughthechannelintothecytosoltoinitiatemusclecontraction.CaMKII,wasabletophosphorylateSer-2814ofRYR2enhancingCa²⁺-sensitivityandincreasingopenprobABIlity.ExcessivephosphorylationofSer-2814leadstoatrialfibrillation,arrhythmiasandsuddendeath

Testedapplications: Westernblot(1:5000dilution),immunofluorescencemicroscopy(1:100). Speciesrecognition: Allmammalianspecies,whenphosphorylatedonSer-2814(orSer-2815rabbit)Antibodyrecognisesepitopedespitesingleresiduedifferenceinepitopebetweenspecies(V2815I;humanvsmouse).

DATASHEET:

Description	Lyophilisedrabbitanti-serum
Immunogen	Syntheticpeptide(TSQVS(PO3H2)VDAAH2819)correspondingtoaminoacidssurroundingthephosphorylatedserineresidueatposition2814ofRyR2(human)conjugatedtoKLH.
Isotype	IgG
Purification	Rawserum
Speciesreactivity	PeptidealignswithRyR2fromallmammalianspecies.Sequencecorrespondsexactlyinrabbitbutdiffersatoneresidue(V2815I)inmouseandrat.Howeverantibodyrecognisesbothsequences.
Testedapplications	WB,IHC
Recommendeddilution	WB1:5000,IHC1:100
Optimization	Optimaldilutionstobedeterminedbyenduser
Storage	Lyophilisedantibodyisstableat4°Cwhenstoredwithdesiccant.Reconstitutelyophilisedpowderin50µlof18MΩH2O,aliquotandstorefrozenat-80°Cfor1year.Avoidfreeze-thawcycles.
Storage	Lyophilised:4°CReconstituted:-80°C
Datasheet	A010-31Lot1209-04 A010-31Lot0513-06
MSDS	A010-31
Regulatorystatement	Productforresearchuseonly.Notintendedfordiagnosticortherapeuticuse.

badrilla公司是一个生命科学公司。主要为制药，生物分子的心血管研究人员提供高质量的产品，并在全球学术机构。badrilla帮助研究人员结合其精细有机蛋白的蛋白质，协调心肌兴奋收缩耦联的翻译后修饰的化学专业知识，心律失常和肥大，和不良反应导致心脏衰竭，以产生最高的完整的研究工具和广泛的应用。