DESCRIPTION:

Highlyspecific,wellvalidatedpolyclonalantiserumtoSERCA2a

 SERCA2aisaCa²⁺pumplocatedinthesarcoplasmicreticulumofcardiacandslow-twitchskeletalmuscle.TheenzymetransportsCa²⁺fromthecytoplasmintotheSRusingthehydrolysisofATPastheenergysourceforthisreaction.TwoCa²⁺aretransportedforeachATPhydrolysed. ThisCa²⁺transportistheprincipalmeansofmusclerelaxationincardiacandslow-twitchskeletalmuscle.TheactivityofSERCA2aismoderatedbyitsinteractionwithphospholamban.SERCA2aisoneisoformofSERCA2:thisisoformdiffersfromSERCA2bandSERCA2cattheextremecarboxyterminusonly. AntibodyA010-20recognisestheC-terminalsequencewhichdistinguishesSERCA2afromSERCA2bandSERCA2c. 

Testedapplications: WesternBlot(1:5000dilution). Speciesrecognition: TheantibodyreactswithSERCA2afromhuman,rat,mouse,rabbit,canine,andbovinespecies.

DATASHEET:

Description	LyophilisedRabbitpolyclonalserumcontainingIgGantibodyspecifictoSERCA2a
Immunogen	Syntheticpeptide(C-LEPAILE997)correspondingtoaminoacidsattheextremeC-terminusofSERCA2a
Isotype	IgG
Purification	Rawserum
Speciesreactivity	TheantibodyrecognisesSERCA2aandbindingisblockedinthepresenceofapeptidecontainingtheepitope.TheantibodyreactswithSERCA2afromhuman,rat,mouse,rabbit,canine,andbovinespecies.
Testedapplications	WB,ELISAandIHCmicroscopy
Recommendeddilution	WB1:5000
Optimization	Optimaldilutionstobedeterminedbyenduser
Storage	Lyophilisedantibodyisstableat4°Cwhenstoredwithdesiccant.Reconstitutelyophilisedpowderin20µlof18MΩH2O,aliquotandstorefrozenat-80°Cfor1year.Avoidfreeze-thawcycles.
Storage	Lyophilised:4°C.Reconstituted:-80°C
Datasheet	A010-20Lot0210-06 A010-20Lot0814-01
MSDS	A010-20
Regulatorystatement	Productforresearchuseonly.Notintendedfordiagnosticortherapeuticuse.

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