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蚂蚁淘在线 / 品牌中心 / Alomone / 阿洛蒙/抗-α；2B肾上腺素能受体（细胞外）抗体/AAR-021/25µl

阿洛蒙/抗-α；2B肾上腺素能受体（细胞外）抗体/AAR-021/25µl

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￥4940.00

货号：AAR-021-25µl

浏览量：127

品牌：Alomone

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商品描述

Cat#:AAR-021

LyophilizedPowder

AntigenIncl.

ShippedatRoomTemp.

Type:Polyclonal

Source:Rabbit

Reactivity:r

Immunogen

Peptide(C)RPEPRGLPQ*SELNQE,correspondingtoaminoacidresidues160-174ofratα_2B-adrenoceptorwithreplacementofcysteine169(C₁₆₉)withserine(*S)(AccessionP19328).2^ndextracellularloop.

Anti-α2B-Adrenergic Receptor (extracellular) Antibody -

Accession(Uniprot)NumberP19328

GeneID24174

PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.

HomologyRat-14/15aminoacidresiduesidentical;mouse-13/15aminoacidresiduesidentical;human-10/14aminoacidresiduesidentical.

PurityAffinitypurifiedonimmobilizedantigen.

FormulationLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN₃.

StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.

Reconstitution25µl,50μlor0.2mldoubledistilledwater(DDW),dependingonthesamplesize.

Antibodyconcentrationafterreconstitution0.8mg/ml.

StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°Cforupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000xg5min).

ControlantigenstoragebeforereconstitutionLyophilizedpowdercanbestoredintactatroomtemperaturefor2weeks.Forlongerperiods,itshouldbestoredat-20°C.

Controlantigenreconstitution100µldoubledistilledwater(DDW).

Controlantigenstorageafterreconstitution-20°C.

PreadsorptionControl1μgpeptideper1μgantibody.

StandardqualitycontrolofeachlotWesternblotanalysis.

Applications:ih,wb

Mayalsoworkin:ic,ifc,ip,lci

Westernblot

Westernblotanalysisofratkidney(lanes1and5),lung(lanes2and6),liver(lanes3and7)lysatesandratskeletalmusclemembranes(lanes4and8):

1.Anti-α_2B-AdrenergicReceptor(extracellular) Antibody(#AAR-021),(1:200).
2.Anti-α_2B-AdrenergicReceptor(extracellular)Antibody,preincubatedwiththecontrolpeptideantigen.

Immunohistochemistry

Expressionofα_2B-Adrenoreceptorinratlung

ImmunohistochemicalstainingofratlungparaffinembeddedsectionsusingAnti-α_2B-AdrenergicReceptor(extracellular)Antibody(#AAR-021),(1:100).α_2B-Adrenoreceptorisexpressedintherespiratoryepitheliumofthebronchioli(arrows).Hematoxilinisusedasthecounterstain.

References

IUPHARRECEPTORDATABASE|ADRENOCEPTORS
Piascik,M.T.andPerez,D.M.(2001)J.Pharmacol.Exp.Ther.298,403.
Link,R.E.etal.(1996)Science273,803.
Makaritsis,K.P.etal.(1999)Hypertension33,14.
Eason,M.G.andLiggett,S.B.(1992)J.Biol.Chem.267,25473.
Pitcher,J.A.etal.(1998)Annu.Rev.Biochem.67,653.
Kurose,H.andLefkowitz,R.J.(1994)J.Biol.Chem.269,10093.

Scientificbackground

Adrenergicreceptors(alsocalledadrenoceptors)arethereceptorsforthecatecholaminesadrenalineandnoradrenaline(calledepinephrineandnorepinephrineintheUnitedStates).Adrenalineandnoradrenalineplayimportantrolesinthecontrolofbloodpressure,myocardialcontractilerateandforce,airwayreactivity,andavarietyofmetabolicandcentralnervoussystemfunctions.

AdrenergicreceptorsaremembersoftheG-proteincoupledreceptor(GPCR)superfamilyofmembraneproteins.Theyshareacommonstructureofsevenputativetransmembranedomains,anextracellularaminoterminus,andacytoplasmiccarboxylterminus.

Adrenoceptorsaredividedintothreetypes:α₁,α₂ andβ-adrenoceptors.Eachtypeisfurtherdividedintoatleastthreesubtypes:α_1A,α_1B,α_1D,α_2A,α_2B,α_2C,β₁,β₂,β₃^1,2.Adrenoceptors areexpressedinnearlyallperipheraltissuesandinthecentralnervoussystem^1,2.

Theα_2B-adrenoceptorhasadistinctpatternofexpressionwithinthebrain,liverlungandkidney,andrecentstudiesusingtheknockoutmousesystemhaveshownthatdisruptionofthisreceptorindeedaffectsmouseviABIlity³,bloodpressureresponsestoα₂-adrenoceptoragoNISTs³ andthehypertensiveresponsetosaltloADIng⁴.

Liketheα_2A-adrenoceptorsubtype,theα_2B-adrenoceptorundergoesshorttermagonistpromoteddesensitization⁵.ThisdesensitizationisduetothephosphorylationofthereceptorbyG-proteincoupledreceptorkinases(GRKs)⁶ whichultimatelypromotesuncouplingofthereceptorfromtheG-proteinsubunit⁷.

LyophilizedPowderControlAntigenIncluded

Clickheretoreceivea25µlfreetrialsample!

Lastupdate:19/02/2019

AlomoneLabsispleasedtoofferahighlyspecificantibodydirectedagainstanextracellularepitopeoftheratα_2B-adrenoceptor.Anti-α_2B-AdrenergicReceptor(extracellular)Antibody(#AAR-021)canbeusedinwesternblotandimmunohistochemistryapplications.Ithasbeendesignedtorecognizeα_2B-adrenoceptorfrommouse,rat,andhumansamples.

Forresearchpurposesonly,notforhumanuse

Westernblot

Westernblotanalysisofratkidney(lanes1and5),lung(lanes2and6),liver(lanes3and7)lysatesandratskeletalmusclemembranes(lanes4and8):

1.Anti-α_2B-AdrenergicReceptor(extracellular) Antibody(#AAR-021),(1:200).
2.Anti-α_2B-AdrenergicReceptor(extracellular)Antibody,preincubatedwiththecontrolpeptideantigen.

Alomone Labs是您离子通道研究的合作伙伴，是离子通道，GPCR和神经信号工具的领先供应商。我们专门生产基础科学研究中使用的一抗，小分子，蛋白质和肽。Alomone成立于1989年，现已成为全世界科学家使用的最全面的离子通道研究工具来源。Alomone的所有产品均经过生物测定验证，并以冻干粉形式提供，因此您可以对它们的生物活性和长保质期充满信心。立即索取信息 Alomone公司作为世界上***的离子通道专业供应商，它的离子通道抗体是世界上*全的、质量也非常好！目前被世界各地的科学家广泛的使用. Alomone Labs Alomone 公司是一家位于耶路撒冷的以色列著名的生物科技公司，专著于提供生命科学细胞生物学试剂和服务。Alomone 公司作为世界上最著名的离子通道专业供应商，它的离子通道抗体是世界上最全的、质量也非常好！目前被世界各地的科学家广泛的使用。试剂

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阿洛蒙/抗-α；2B肾上腺素能受体（细胞外）抗体/AAR-021/25µl

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