绝对抗体/Ab00295-7.1抗Ly6G[1A8]/Ab00295-7.1/200µg

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¥6384.00
货号:Ab00295-7.1
浏览量:127
品牌:Absolute Antibody
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商品描述
Description:RecombinantmonoclonalantibodytoLy6G.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridoma1A8.
SpeciesandIsotype:RatIgG2a,kappa
CloneNumber:1A8
UniProtAccessionNumberofTargetProtein:P35461
AlternativeName(s)ofTarget:Ly-6G;GR-1;GR1;Lymphocyteantigen6G
PublishedApplication(s):FC;depletion
PublishedSpeciesReactivity:Mouse
Immunogen:LEW/Nratsimmunizedwith1.5x10E8Ly-6G-transfectedEL4Jcells
Specificity:RecognisesthemurineGPI-anchoredproteinLy6G,aMarkerofgranulocytedifferentiation,maturationand,togetherwithLy6C,acomponentoftheGranulocyteReceptor-1Antigen(Gr-1).Unlikeanothercommonlyusedclone,RB6-8C5,1A8doesnotbindLy6C.
ApplicationNotes:Neutrophilsarecrucialcomponentsofourimmunesystem.Ly6Gishighlyexpressedonneutrophils,whichallowsthe1A8clonetobeusednotonlyindetectionofneutrophils,butalsoinselectivedepletioninvivo.Itmayalsobeusedasanegativeselectionmarkerforbone-marrowderivedmacrophages,whichshouldbeLy6G(-)andF4/80(+)(seeourF4/80rangeofantibodies).
AntibodyFirstPublishedin:
FlemingTJ,FlemingML,MalekTR.SelectiveexpressionofLy-6Gonmyeloidlineagecellsinmousebonemarrow.RB6-8C5mAbtogranulocyte-differentiationantigen(Gr-1)detectsmembersoftheLy-6family.JournalofImmunologyPMID:8360469Noteonpublication:Describesproductionof1A8andidentificationofLy6Gasitstarget.

ProductForm

Purification:ProteinAaffinitypurified
Suppliedin:PBSonly.
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.

Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals. Absolute Antibody英国牛津大学Hutchings博士和Barclay教授创办的第二代抗体公司,可以在两周内提供100mg级的工程化抗体,并且没有动物成分,批间差很小,消除因补体和Fc受体造成的背景,使结果更干净。该公司的成立顺应了Nature杂志为首的科学界提倡改变目前抗体供应混乱状况的时代潮流。