绝对抗体/抗-5-羟甲基胞嘧啶[AB3/63.3]/200μg/Ab00862-23.0

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¥5400.00
货号:Ab00862-23.0
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品牌:Absolute Antibody
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商品描述

AlternativeName(s)ofTarget:5hmc;MABE176;5hmeC;5"hydroxymethyl;cytosine;5"OHmethylcytosine;5"OHmeC;5hmc;5-hmCImmunogen:5-HydroxymethylcytosineconjugatedtoBSA.

Specificity:Theanti-5-Hydroxymethylcytosineantibody,cloneAB3/63.3,detects5-hydroxymethylcytosine(hmc,5hmc),butnot5-methylcytosineorunmethylatedcytosine.

ApplicationNotes:Thisantibodycanbeusedtodetect5hmCbyimmunofluorescenceanddotblot.Zhangetal.(2014,PMID:24427299)usedtheoriginalratIgG2aformat(underthenameMABE176)inanimmunoprecipitationexperiment.

Antibodyfirstpublishedin:Ficzetal.Dynamicregulationof5-hydroxymethylcytosineinmouseEScellsandduringdifferentiation.Nature.2011May19;473(7347):398-402PMID:21460836Noteonpublication:Describesthegenerationanduseinimmunofluorescenceoftheoriginalantibody.

Absolute Antibody英国牛津大学Hutchings博士和Barclay教授创办的第二代抗体公司,可以在两周内提供100mg级的工程化抗体,并且没有动物成分,批间差很小,消除因补体和Fc受体造成的背景,使结果更干净。该公司的成立顺应了Nature杂志为首的科学界提倡改变目前抗体供应混乱状况的时代潮流。