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蚂蚁淘在线 / 品牌中心 / Absolute Antibody / absoluteantibody/Ab00906-10.3 Anti-ZIKV soluble envelope protein [z23]/Ab00906-10.3/ 200 µg
商品描述
Description:RecombinantmonoclonalantibodytoZIKVsolubleenvelopeprotein.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaz23.ThisantibodywascreatedusingourproprietaryFcSilent™engineeredFcdomaincontainingkeypointmutationsthatabrogatebindingtoFcgammareceptors.
SpeciesandIsotype:HumanIgG1,FcSilent™,kappa
CloneNumber:z23
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):Block
PublishedSpeciesReactivity:Zikavirus
Immunogen:ThisantibodywasderivedfrommemoryBcellsspecificforpurifiedmonomericZikavirussolubleenvelopeprotein,whichwereisolatedbyFACSfromthebloodofapatient20dayspost-infectionwithzikavirus.Togeneratefull-lengthmonoclonalantibodies,thevariableregionswerethenclonedintohumanIgG1constantregion.
Specificity:ThisantibodybindatertiaryepitopeinthezikavirussolubleenvelopeproteindomainIII.
ApplicationNotes:ThisantibodyspecificallyandpotentlyneutralisesZikavirusinvitro,anddoesnotcross-reactwithstrains1-4ofdenguevirus,whichminimisestheriskofantibody-dependentenhancement(Wangetal,2016).Inamurinemodel,thisantibodyconferspostexposureprotectionagainstZikavirus(Wangetal,2016).
AntibodyFirstPublishedin:
Wangetal.MoleculardeterminantsofhumanneutralizingantibodiesisolatedfromapatientinfectedwithZikavirusScienceTranslationalMedicine,December14,2016,Vol.8(369),p.369ra179Noteonpublication:Describestheoriginalgenerationandcharacterisationofthisantibody.
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals. Absolute Antibody英国牛津大学Hutchings博士和Barclay教授创办的第二代抗体公司，可以在两周内提供100mg级的工程化抗体，并且没有动物成分，批间差很小，消除因补体和Fc受体造成的背景，使结果更干净。该公司的成立顺应了Nature杂志为首的科学界提倡改变目前抗体供应混乱状况的时代潮流。 SpeciesandIsotype:HumanIgG1,FcSilent™,kappa
CloneNumber:z23
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):Block
PublishedSpeciesReactivity:Zikavirus
Immunogen:ThisantibodywasderivedfrommemoryBcellsspecificforpurifiedmonomericZikavirussolubleenvelopeprotein,whichwereisolatedbyFACSfromthebloodofapatient20dayspost-infectionwithzikavirus.Togeneratefull-lengthmonoclonalantibodies,thevariableregionswerethenclonedintohumanIgG1constantregion.
Specificity:ThisantibodybindatertiaryepitopeinthezikavirussolubleenvelopeproteindomainIII.
ApplicationNotes:ThisantibodyspecificallyandpotentlyneutralisesZikavirusinvitro,anddoesnotcross-reactwithstrains1-4ofdenguevirus,whichminimisestheriskofantibody-dependentenhancement(Wangetal,2016).Inamurinemodel,thisantibodyconferspostexposureprotectionagainstZikavirus(Wangetal,2016).
AntibodyFirstPublishedin:
Wangetal.MoleculardeterminantsofhumanneutralizingantibodiesisolatedfromapatientinfectedwithZikavirusScienceTranslationalMedicine,December14,2016,Vol.8(369),p.369ra179Noteonpublication:Describestheoriginalgenerationandcharacterisationofthisantibody.
ProductForm
Purification:ProteinAaffinitypurifiedSuppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
