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- Primary Antibodies
- Recombinant Antibodies from Human Patients
- Anti-Allergen Antibodies
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- Recombinant Isotype Controls
- 抗过敏原抗体
- 重组F4/80克隆CI:A3-1
- 体内研究用重组抗体
- Recombinant F4/80 Clone CI:A3-1
- Research-Grade Biosimilars
- 关注来自人类患者的重组抗体
- 同型对照
- 重组免疫球蛋白Fc结构域（Ig-Fc结构域）
- 人源性重组抗体
- 研究级生物仿制药
- 其他产品
- 抗病毒抗体
- 重组自由轻链
- Antibodies to Epitope Tags
- Anti-Virus Antibodies
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- Absolute Antibody
- Absolute antibody
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公司地址
苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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https://www.ebiomall.com
商品描述
Description:RecombinantmonoclonalantibodytoIgE.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaTES-C21.ThisisaFabfragmentwithahis-tag.
CloneNumber:TES-C21
UniProtAccessionNumberofTargetProtein:
AlternativeName(s)ofTarget:ImmunoglobulinE
PublishedApplication(s):block;ELISA
PublishedSpeciesReactivity:Human
Immunogen:PolyclonalhumanIgE.
Specificity:
ApplicationNotes:TheantibodybindsspecificallytoIgE,animmunoglobulinisotypesecretedbyuponstimulationofBcellsbyinterleukinsIl-4andIL-13.IgEprovidesimmunitytoparasitessuchashelminthsandPlasmodiumfalciparum.TheimmunoglobulinalsoplaysacentralroleinthedevelopmentofTypeIhypersensitivityreactionsandallergicdiseasessuchasasthma,sinusitisandfoodallergies.TheseallergicresponsesaretriggeredbythebindingofIgEtothehighaffinityreceptorFcεRI,expressedonthesurfaceofbasophilsandmastcells.BindingofIgEcausescross-linkingofthereceptor,inducingdegranulationandreleaseofinflammatorymediators,particularlyofhistamine.ThemonoclonalantibodyTES-C21bindstosecretedIgEandtoIgEexpressedonthesurfaceofIgE-producingBcells,therebyinhibitingIgEbindingtoFcεRIandthereleaseofhistaminefrommastcells.Themonoclonalantibodycanhavediagnosticapplications,suchasforidentifyingandquantifyingIgE-expressingBcellsandIgElevelsinserumsamples,andtherapeuticapplicationsinthetreatmentofallergies.FurThermore,theantibodycanconjugatedtocytotoxicdrugsanddeliverthemspecificallytoIgE-producingBcells.
AntibodyFirstPublishedin:
KolbingerF,SaldanhaJ,HardmanN,BendigMM.Humanizationofamouseanti-humanIgEantibody:apotentialtherapeuticforIgE-mediatedallergies.ProteinEng.1993Nov;6(8):971-80.PMID:8309946Noteonpublication:DescribesthetherapeuticpotentialofthemurinemonoclonalantibodyTES-C21inthetreatmentofIgE-mediatedallergies,andtheproductionofahumanizedversionoftheantibodytoreducetheimmunogenicityinhumans.
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals. Absolute Antibody英国牛津大学Hutchings博士和Barclay教授创办的第二代抗体公司，可以在两周内提供100mg级的工程化抗体，并且没有动物成分，批间差很小，消除因补体和Fc受体造成的背景，使结果更干净。该公司的成立顺应了Nature杂志为首的科学界提倡改变目前抗体供应混乱状况的时代潮流。 ThischimerichumanantibodywasmadeusingthevariabledomainsequencesoftheoriginalMouseIgGformat,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.
SpeciesandIsotype:HumanFabfragment,His-Tagged,kappaCloneNumber:TES-C21
UniProtAccessionNumberofTargetProtein:
AlternativeName(s)ofTarget:ImmunoglobulinE
PublishedApplication(s):block;ELISA
PublishedSpeciesReactivity:Human
Immunogen:PolyclonalhumanIgE.
Specificity:
ApplicationNotes:TheantibodybindsspecificallytoIgE,animmunoglobulinisotypesecretedbyuponstimulationofBcellsbyinterleukinsIl-4andIL-13.IgEprovidesimmunitytoparasitessuchashelminthsandPlasmodiumfalciparum.TheimmunoglobulinalsoplaysacentralroleinthedevelopmentofTypeIhypersensitivityreactionsandallergicdiseasessuchasasthma,sinusitisandfoodallergies.TheseallergicresponsesaretriggeredbythebindingofIgEtothehighaffinityreceptorFcεRI,expressedonthesurfaceofbasophilsandmastcells.BindingofIgEcausescross-linkingofthereceptor,inducingdegranulationandreleaseofinflammatorymediators,particularlyofhistamine.ThemonoclonalantibodyTES-C21bindstosecretedIgEandtoIgEexpressedonthesurfaceofIgE-producingBcells,therebyinhibitingIgEbindingtoFcεRIandthereleaseofhistaminefrommastcells.Themonoclonalantibodycanhavediagnosticapplications,suchasforidentifyingandquantifyingIgE-expressingBcellsandIgElevelsinserumsamples,andtherapeuticapplicationsinthetreatmentofallergies.FurThermore,theantibodycanconjugatedtocytotoxicdrugsanddeliverthemspecificallytoIgE-producingBcells.
AntibodyFirstPublishedin:
KolbingerF,SaldanhaJ,HardmanN,BendigMM.Humanizationofamouseanti-humanIgEantibody:apotentialtherapeuticforIgE-mediatedallergies.ProteinEng.1993Nov;6(8):971-80.PMID:8309946Noteonpublication:DescribesthetherapeuticpotentialofthemurinemonoclonalantibodyTES-C21inthetreatmentofIgE-mediatedallergies,andtheproductionofahumanizedversionoftheantibodytoreducetheimmunogenicityinhumans.
ProductForm
Purification:PurifiedbyImmobilizedMetalAffinityChromatographySuppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
