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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
MW:271.3Da
CASRegistry#:37762-06-4
Formula:C13H13N5O2
Description:
ZaprinastisacGMP-specificPDEinhibitorwhichmoderatelyinhibitsPDE5andPDE6.ItweaklyinhibitsPDE9,PDE10andPDE11.Sildenafil(Viagra™)wasdevelopedfromZaprinast,whichenhancesthevasodilatoryeffectsofnitricoxideinarangeofvasculartissuesbyprolongingthecGMP-mediatedactivationofcGMP-dependentproteinkinase.Also,GPR35isactivatedbyZaprinast.
Purity:
≥98%byHPLC
BIOLOGicalActivity:
ZaprinastinhibitsPDE5andPDE6withIC50valuesof0.5-0.76µMand0.15µM,respectively.
Solubility:
SolubleinDMSOandDMF,purgedwithaninertgas.SolubilityinDMSOandDMFis~10mg/ml.Formaximumsolubility,dissolveinDMFandthendilutewiththeaqueousbufferofchoice.
Format:
Acrystallinesolid.
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Nakamizo,T.,etal.,J.Neurosci.Res.2003;71:485-495.
2.Gibson,A.,etal.,Eur.J.Pharmacol.2001;411:1-10.
3.Taniguchi,Y.,etal.,FEBSLett.2006;580:5003-5008.
2.Gibson,A.,etal.,Eur.J.Pharmacol.2001;411:1-10.
3.Taniguchi,Y.,etal.,FEBSLett.2006;580:5003-5008.
ScientificCategory:
PDE
ProductType:
Inhibitor
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