Overview

Endothelialcellsarehighlydynamiccellsthatformtheinnerliningofbloodvessels.Inadditiontotheirstructuralrole,endothelialcellsregulatethepassageofsubstancesbetweenthebloodstreamandsurroundingtissue.Theyalsosecretemediatorsthatinfluencevascularhemodynamics,inflammation,celltrafficking,andtheremodelingandformationofnewbloodvessels.Endothelialcelldysfunctionisassociatedwithavarietyofdiseasesincludingatherosclerosis,coronaryarterydisease,hypertension,andinflammatorydisorders.DerivedfromhumaniPScells,CDI’siCell®EndothelialCellsprovideareliable,reproducible,andphysiologicallyrelevantsourceofcellsforvasculardiseasemodeling,drugscreening,andvasculartissueengineeringapplications.Benefitsinclude:•>90%CD31+/CD105+populationsacrosslotsandmultiplepassages•VEGF-mediatedproliferation,sprouting,migration,andinvasion•TNFα-mediatedupregulationofadhesionmolecules•Thrombin-sensitivebarrierfunction•AcetylatedLDLuptake•Shearstress-inducedalignment•2Dand3Dcapillary-likenetworkformationBroadFunctionandApplicationAssayedasapurecultureorinco-culturewithotherdifferentiatedcelltypestorecapitulatenativetissuearchitecture,iCell®EndothelialCellsenableavarietyofnovelapplications:•Vasculartissueengineering:Decellularizedorgan(e.g.kidney)scaffoldapproaches•Vasculartissueengineering:Naturalmatricesandbioengineeringscaffolds(e.g.microfluidicdeviceandbioreactorsystemcultures)•Angiogenesisandwoundhealing:ProvidingrelevantBIOLOGyforthestudyofbloodvesselformationandremodelingrelevanttocancer,chronicinflammatory,anddegenerativediseases•InfectiousdiseasestudiesCertainproductsareonlyavailableinselectterritories.PleasecontactyourlocalSalesRepresentativeorProduct&ScientificSupportattechsupport@stemcell.comforfurtherinformation."