ABL1protooncogeneencodesacytoplasmicandnuclearproteintyrosinekinasethathasbeenimplicatedinprocessesofcelldifferentiation,celldivision,celladhesion,andstressresponse.ActivityofABLproteinisnegativelyregulatedbyitsSH3domainanddeletionoftheSH3domainturnsABL1intoanoncogene.Translocationandhead-to-tailfusionoftheBCRandABL1genesispresentinmanycasesofchronicmyelogeneousleukemia.TheDNA-bindingactivityoftheubiquitouslyexpressedABL1tyrosinekinaseisregulatedbyCDK1-mediatedphosphorylation,suggestingacellcyclefunctionforABL1.||Source:|RecombinantproteincorrespondingtohumanABL1,fusedtoHis-TagatN-terminal,expressedinInsectcells.||MolecularWeight:|~135kD||SpecificActivity:|871nmol/min/mgasperactivityassayprotocol.||Endotoxin:|<1EU/ug(LAL)||StorageandStABIlity:|Aliquottoavoidrepeatedfreezingandthawingandstoreat-70°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Source:Recombinant,Insectcells|Purity:Purified(~70-90%)|Concentration:Asreported|Form:Suppliedasaliquidin50mMsodiumphosphate,pH7.0,300mMsodiumchloride,150mMimidazole,0.1mMPMSF,0.2mMDTT,25%glycerol.||ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplicationswithouttheexpressedwrittenauthorizationofUnitedStatesBIOLOGical. USBio的生物化学品，抗体，重组蛋白，细胞培养基和分子生物学试剂盒几乎用于所有科学应用和环境，包括基因组研究，生物技术，药物开发和疾病诊断。USBio产品从经济实惠的研究数量到更大的批量可用于工艺开发和生产。我们的客户包括位于美国和国外的大多数*的制药和生物技术公司。