- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
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Overview:
LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. LATS2 interacts with a negative regulator of p53 and function in a positive feedback loop with p53 that responds to cytoskeleton damage and this interaction provokes centrosome/mitotic apparatus dysfunction (1). LATS2 plays an essential role in the maintenance of mitotic fidelity and genomic integrity (2).
Gene Aliases:
none
Genbank Number:
NM_014572
References:
1. Aylon, Y. et.al: A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev. 20: 2687-2700, 2006.2. McPherson, J. P. et.al: Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J. 23: 3677-3688, 2004.
