- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
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- 脂质底物
- E2
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- E3
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Overview:
PKCαisamemberoftheproteinkinaseC(PKC)familyofserine-andthreonine-specificproteinkinasesthatcanbeactivatedbycalciumandthesecondmessengerdiacylglycerol.PKC-alphahasbeenreportedtoplayrolesinmanydifferentcellularprocesses,suchascelladhesion,celltransformation,cellcyclecheckpoint,andcellvolumecontrol(1).PKCαhasbeenassignedtothechromosomeregion17q22-q23.2andhasbeenidentifiedasafundamentalregulatorofcardiaccontractilityandCa(2+)handlinginmyocytes(2).
GeneAliases:
PRKCA;MGC82897
GenbankNumber:
BC078065
References:
1.Coussens,L.etal:Multiple,distinctformsofbovineandhumanproteinkinaseCsuggestdiversityincellularsignalingpathways.Science233:859-866,1986.2.Braz,JC.etal:PKC-alpharegulatescardiaccontractilityandpropensitytowardheartfailure.NatureMed.10:248-254,2004.
