- Peptide Substrates
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- E2
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- E3
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- SignalChem|生产厂家|价格信息
- signalchem
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Overview:
LATS1isaputativeserine/threoninekinasethatlocalizestothemitoticapparatusandcomplexeswithcellcyclecontrollerCDC2kinaseinearlymitosiswhichisphosphorylatedinacell-cycledependentmanner.TheN-terminalregionoftheproteinbindsCDC2toformacomplexshowingreducedH1histonekinaseactivitywhichindicatingaroleasanegativeregulatorofCDC2/cyclinAandtheC-terminalkinasedomainbindstoitsownN-terminalregion,suggestingpotentialnegativeregulationthroughinterferencewithcomplexformationviaintramolecularbinding(1).LATS1actasatumorsuppressorandplayanimportantroleinthedevelopmentofsoft-tissuesarcomas,ovarianstromalcelltumorsandahighsensitivitytocarcinogenictreatments(2).
GeneAliases:
WARTS;wts
GenbankNumber:
NM_004690
References:
1.Tao,W.et.al:HumanhomologueoftheDrosophilamelanogasterlatstumoursuppressormodulatesCDC2activity.NatureGenet.21:177-181,1999.2.St.John.et.al:MicedeficientofLats1developsoft-tissuesarcomas,ovariantumoursandpituitarydysfunction.NatureGenet.21:182-186,1999.
