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商品描述
Overview:
VASPorVasodilator-stimulatedphosphoproteinisamemberoftheEna-VASPproteinfamilywhichcontainsanEHV1N-terminaldomainthatbindsproteinscontainingE/DFPPPPXD/EmotifsandtargetsEna-VASPproteinstofocaladhesions(1).VASPalsocontainsproline-richdomainthatbindSH3andWWdomain-containingproteins.VASPisassociatedwithfilamentousactinformationandlikelyplaysakeyroleincelladhesionandmotility.VASPisalsoinvolvedintheintracellularsignalingpathwaysthatregulateintegrin-extracellularmatrixinteractions.VASPisregulatedbythecyclicnucleotide-dependentkinasesPKAandPKG.
References:
1.Brindle,NPJ.etal:Thefocal-adhesionvasodilator-stimulatedphosphoprotein(VASP)bindstotheproline-richdomaininvinculin.Biochem.J.318753-757,1996.
