Overview:

PAD6 or PADI6 is a member of the peptidylarginine deiminases which convert arginine residues to citrulline residues in the presence of calcium ions. The PAD family members are thought to be involved in multiple sclerosis and rheumatoid arthritis pathophysiology, and they play a role in epidermis homeostasis (1). PAD6 is essential for formation of a novel oocyte-restricted fibrous structure, the cytoplasmic lattices (CPLs). PAD6/CPL superstructure plays a key role in regulating microtubule-mediated organelle positioning and movement (2).

Gene Aliases:

PADI6

Genbank Number:

NM_207421

References:

1. Vossenaar, E R. Et al: PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease. Bioessays. 2003 Nov;25(11):1106-18.2. Kan, R. Et al: Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices. Dev Biol. 2011 Feb 15;350(2):311-22.