- 细胞因子
- Dihydropyrimidinase and Proteins
- Regulatory proteins
- 授予称号
- Peptide Substrates
- Isoform Specific Antibodies
- Deacetylase & Demethylase Proteins
- Acetyl & Methyltransferase Proteins
- siRNA Controls
- Cell Stress and Chaperone Proteins
- 激酶
- 双加氧酶与蛋白质
- Transcription Proteins
- Carbohydrate Kinases
- 表观遗传酶抑制剂
- Growth Factors
- 脂类激酶
- Phospholipase C and Proteins
- Mutant Kinases
- Oligo Substrates
- Fluorescent and Color Proteins
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Overview:
CDC25C(alsoknownascelldivisioncycle25homologC)isamemberoftheCDC25phosphatasefamily.CDC25Cishighlyconservedduringevolutionanditplaysakeyroleintheregulationofcelldivision.CDC25Cactivatesthepartiallypurifiedp34(cdc2)/cyclinBcomplexanddirectsthedephosphorylationofcyclinB-boundCDC2andtriggersentryintomitosis(1).CDC25Calsosuppressesp53-inducedgrowtharrest.TheregulationofCDC25Bphosphorylationbyp38isacriticaleventforinitiatingtheG2/McheckpointafterultravioletrADIation(2).
GeneAliases:
CDC25
GenbankNumber:
BC019089
References:
1.Gould,K.L.et.al:Complementationofthemitoticactivator,p80(cdc25),byahumanprotein-tyrosinephosphatase.Science250:1573-1576,1990.2.Bulavin,D.V.et.al:InitiationofaG2/Mcheckpointafterultravioletradiationrequiresp38kinase.Nature411:102-107,2001.
