- Peptide Substrates
- Binding Proteins
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- E2
- Assay Buffer and Co-factors
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- E3
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- SignalChem|生产厂家|价格信息
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/10 ug/B10-12GH-10
Overview:
BTK(alsoknownasBrutontyrosinekinase)playsacrucialroleinB-lymphocytedifferentiationandactivation.BTKinteractswithSRChomology3domainsofFYN,LYNandHCKthatareactivateduponstimulationofB-andT-cellreceptors(1).DefectsintheBTKgenecauseAgammaglobulinemia,anX-linkedimmunodeficiencycharacterizedbyfailuretoproducematureBlymphocytecellsandassociatedwithafailureofIgheavychainrearrangement.TheuniqueroleofBTKmakesitadesirabletargetforpotentialanti-cancer,anti-inflammatoryandanti-viralagentsaswellasothertreatments(2).
GeneAliases:
AT;ATK;BPK;XLA;IMD1;AGMX1;PSCTK
GenbankNumber:
NM_000061
References:
1.Cheng,G.etal:BindingofBruton"styrosinekinasetoFyn,Lyn,orHckthroughaSrchomology3domain-mediatedinteraction.Proc.Nat.Acad.Sci.91:8152-8155,1994.2.Vassilev,AO.etal:TherapeuticpotentialofinhibitingBruton"styrosinekinase,(BTK).CurrPharmDes.2004;10(15):1757-66.
