- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
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Overview:
PAD2isamemberofthepeptidylargininedeiminasefamilyofenzymes,whichcatalyzethepost-translationaldeiminationofproteinsbyconvertingarginineresiduesintocitrullinesinthepresenceofcalciumions.PAD2haspeptidylargininedeiminaseactivityagainstsyntheticsubstrates(1).PAD2ismainlyexpressedinthecentralnervoussystem,skeletalmuscle,spinalcord,cerebrum,cerebellum,andsuBMAxillarygland(2).PAD2playaroleintheonsetandprogressionofneurodegenerativehumandisorders,includingAlzheimerdiseaseandmultiplesclerosis,andithasalsobeenimplicatedinglaucomapathogenesis.
GeneAliases:
PADI2;mKIAA0994
GenbankNumber:
BC049947
References:
1.Ishigami,A.et.al:HumanpeptidylargininedeiminasetypeII:molecularcloning,geneorganization,andexpressioninhumanskin.Arch.Biochem.Biophys.407:25-31,2002.2.Watanabe,K.et.al:IsolationandcharacterizationofCDNAclonesencodingratskeletalmusclepeptidylargininedeiminase.J.Biol.Chem.264:15255-15260,1989.
