References:

1. Shamji AF et al: Integration of growth factor and nutrient signaling: implications for cancer biology. Mol. Cell 2003; 12:271-80.2. Inoki K et al: Signaling by target of rapamycin proteins in cell growth control. Microbiol. Mol. Biol. Rev. 2005; 69:79-100.3. Tabancay Jr AP et al: Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. J. Biol. Chem. 2003; 278:39921-30.4. Inoki K et al: Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 2003; 17:1829-34.