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商品描述
Overview:
EPHB2isamemberoftheEphfamilyofreceptortyrosinekinasesthatmediateneuro-developmentalprocessessuchasboundaryformation,axonguidance,vasculogenesisandcellmigration.ActivatedEPHB2regulatestheactivityofthenon-receptortyrosinekinaseAbl(1).EPHB2isoverexpressedinanumberoftumors,particularlyglioblastoma.Infact,EPHB2overexpressionleadstoincreasedgliomacellmigrationandinvasion(2).
References:
1.Yu,HH.etal:MultiplesignalinginterationofAblandArgkinaseswiththeEPhB2receptor.Oncogene.2001Jul5;20(30):3995-4006.2.Nakada,M.etal:ThephosphorylationofEphB2receptorregulatesmigrationandinvasionofhumangliomacells.CancerRes.2004May1;64(9):3179-85.
