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0512-67156496
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商品描述
Overview:
ASK1,alsoknownasMAPKKK5,activatesMKK3,MKK4(SEK1),andMKK6.OverexpressionofASK1inducesapoptoticcelldeath,andASK1isactivatedincellstreatedwithtumornecrosisfactor-alpha(1).ASK1interactswithmembersoftheTRAFfamilyandisactivatedbyTRAF2intheTNF-signalingpathway.AfteractivationbyTRAF2,ASK1activatesMKK4,whichinturnactivatesJNK.Thus,ASK1isamediatorofTRAF2-inducedJNKactivation(2).
References:
1.Ichijo,H.etal:InductionofapoptosisbyASK1,amammalianMAPKKKthatactivatesSAPK/JNKandp38signalingpathways.Science275:90-94,1997. 2.Nishitoh,H.etal:ASK1isessentialforJNK/SAPKactivationbyTRAF2.Molec.Cell2:389-395,1998.
