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蚂蚁淘在线 / 品牌中心 / Signalchem / Signalchem/Anti-phospho-STK10-a (Ser482 Ser486 Ser490)/100 ul/S29-165R-100
商品描述
Overview:
Polo-likekinase(PLK)playsanimportantroleincellcycleregulation.PLKisalsorequiredforbipolarspindleformation,activationoftheanaphase-promotingcomplex/cyclosome,andcytokinesis.DeregulationofPLKsoftenresultsinabnormalitiesincentrosomeduplication,maturationand/ormicrotubuledynamics(1).STK10-a,whichisalsoknownasPLKKislikelyresponsIBLeforactivatingPLK.STK10-aitselfisactivatedbyphosphorylationatSer482,Ser486andSer490(2).
References:
1.Nigg,EA.etal:Dynamicchangesinnucleararchitectureduringmitosis:ontheroleofproteinphosphorylationinspindleassemblyandchromosomesegregation.ExpCellRes.1996Dec15;2292.EriksonEetal.Afeedbackloopinthepolo-likekinaseactivationpathway.JBiolChem.2004,279:32219-32224.
