Overview:

SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily. The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm (1). Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer (2). There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer (3). SIK3 is a novel tumor-associated antigen (TAA).

References:

1. Al-Hakim A.K., et.al: 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. J. Cell Sci. 118:5661-5673(2005).2. Charoenfuprasert S, et.al: Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer. Oncogene. 2011 Aug 18;30(33):3570-84.3. Sjoeblom T. et.al: The consensus coding sequences of human breast and colorectal cancers. Science 314:268-274(2006).