来自HMGB1的IBL/BoxA,人类和;小鼠,无LPS-2.5 mg/REHM014/

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货号:REHM014
浏览量:127
品牌:IBL
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全国联保
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商品描述
Typerecombinantprotein
AvailableSizes2.5mg
RegulatoryStatus:Forresearchuseonly
Detailsfor: BoxAfromHMGB1,human&mouse,LPS-free-2.5mg
BoxAisoneofthehighlyconservedDNAbindingdomainsofHMGB1protein(HMGboxes).

BoxAisanantagoNISTforHMGB1bindingtoitsreceptorRAGE,andinhibitsHMGB1cytokineeffectsinvivo.TheBoxAweprovidehasnodifferencefromthesequenceofthehumanormouseHMGB1,andasaself-antigenelicitsverylowimmunologicalresponses.

BoxAprotectsagainstsepsisinamouseperitonitismodel(Yangetal.Reversingestablishedsepsiswithantagonistsofendogenoushigh-mobilitygroupbox1.ProcNatlAcadSciUSA2004,101:296-301),andfromhepatitisinamousemodelofHBVinfection(Sitiaetal.TreatmentwithHMGB1inhibitorsdiminishesCTL-inducedliverdiseaseinHBVtransgenicmice.JLeukocBiol2007,81:100-7).

DendriticcellspromotetheirownmaturationandTcellproliferation,survivalandTh1differentiationbysecretingHMGB1,andBoxAinhibitstheseactivities(Dumitriuetal.ReleaseofHMGB1bydendriticcellscontrolsTcellactivationviathereceptorforadvancedglycationendproducts(RAGE).JImmunol2005,174:7506-15).

BoxAalsoinhibitsthechemotacticactivityofHMGB1onendothelialcellsandfibroblasts,andthemitogenicactivityofHMGB1forstemcells(MEBianchi,unpublished).
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
iBL的Tecan由四名工程师于1980年在瑞士Hombrechtikon村成立,旨在开发测量,分析和实验室自动化设备。最初的办公室位于经过翻新的农舍中,这是首席执行官兼创始人亨氏·阿普兰纳普(Heinz Abplanalp)的家庭住宅。