Description	T4EndonucleaseV (T4pyrimidinedimerglycosylase, T4PDG),hasbothDNAN-glycosylaseandapurinic/apyrimidiniclyase(APlyase)activities.Thisenzyme recognizes cis-syn-cyclobutanepyrimidinedimersinDNAcausedbyultraviolet(UV)irrADIation,andtheendonucleolyticactivitycleavesthephosphodiesterbondattheAPsite.
Applications	StudyofUVdamagetoDNAanditsrepair,includingDNAdamageinsinglecells Singlecellgelelectrophoresis(cometassay)
Source	PurifiedfromanE.colistraincarryingaplasmidencodingT4denVgene.
Components	T4EndonucleaseV:10,000units/mlin10mMTris-HCl,100mMNaCl,0.1mMDTT,0.1mMEDTA,50%Glycerol,pH7.5@25°C
UnitDefinition	OneunitofT4EndonucleaseVconverts1µgofUV-irradiatedplasmidDNAfromcovalentlyclosedcirclestonickedformin30minutesat37°C.
QualityControl	Theabsenceofnonspecificexo-andendonucleaseactivitiesandRNaseactivityisconfirmedbyappropriatequalitytest.
StorageCondition	-20°C

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