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- Coutinho,D.C. etal. (2013) J.ReninAngiotensinAldosteroneSyst. 15,480.
AlomoneLabsAngiotensinA(1-8)activatesAT1RexpressedinCHO-K1-mtAequorin-Gα16cells.Ca2+ responsewasdetectedbymeasuringaequorin-derivedfluorescencefollowingapplicationof AngiotensinA )1-8) (#SPA-105)or AngiotensinII (#GPA-100)atdifferentconcentrations.
- 1.Coutinho,D.C. etal. (2013) J.ReninAngiotensinAldosteroneSyst. 15,480.
- 2.Brasch,H. etal. (1993) Hypertension 22, 699.
AngiotensinA(1-8)isanangiotensinIIderivative,avasoconstrictorpeptideoftherenin–angiotensinsystem(RAS)thatactsasanangiotensinreceptortype1and2(AT1RandAT2R)agonist.
ThispeptidewasfirstdiscoveredinthehumanplasmaandthesoledifferencebetweenAngAandAngIIisAla1residueinsteadofAsp1.AngAissynthesizedbyenzymaticdecarboxylationofAsp1oftheAngIIsequence1.
AngiotensinIismetabolizedtothevasoconstrictingoctapeptideangiotensinIIbyacirculatingconvertingenzyme(ACE)byremovaloftwoC-terminalresidues.It"sanaturalhormonewhichthebodyproducesinordertomaintainnormalregulationofcardiovascularfunction.
AngIIisaprimaryeffectorpeptideoftheRASinavarietyoftissuesandisamajortargetforbloodpressureloweringdrugs2.
StudiesshowthatAngAhastheABIlitytoelicitpressorandrenalvasoconstrictorresponsesinnormotensiveandhypertensiverats.Inisolatedperfusedratkidney,thepeptidecausesavasoconstrictiveeffectdependentonAT1receptors1.
AngiotensinA(1-8)(#SPA-105) isahighlypure,synthetic,andbiologicallyactivepeptide.
