- Lc laboratories|阿西替尼, 游离碱
- 重磅!珀金埃尔默3.83亿美元收购Horizon Discovery_资讯中心_
- 仪表网仪表展览网,仪器仪表交易信息门户行业网站、资讯平台!
- Development and characterization of a novel antiOX40 antibody fo...
- Discovery Antibodies_代理
- lifesensors 特约代理
- 生物医药的前沿进展与市场趋势,看各位大咖怎么谈
- 纪录片频道 腾讯视频 QQ
- 第十届抗体药物及新药研发高峰会总日程——EBC2020|药物|...
- HBV RNA检测技术盘点:RTqPCR VS RNA捕获探针法|rna|hbv|pcr_网易订阅
- 柯云路记录的《生命科学探索孙储琳1》
- PWR0 600 50R/J Metallux
Lyophilized Powder This product is freeze dried. All water molecules have been removed.
Bioassay Tested Every lot is tried & tested in a relevant biological assay.
Our Bioassay
-
- Bolden, C. et al. (1992) J. Pharmacol. Exp. Ther. 260, 576.
- Sudo, Y. et al. (1999) Life Sci. 64, PL99.
- Brocks, D.R. (1999) J. Pharm. Pharmaceut. Sci. 2, 39.
-
Alomone Labs Biperiden hydrochloride inhibits carbachol’s effect on M1 mAChR expressed in C6 cells.Cells were loaded with Fluo-3 AM and changes in intracellular Ca2+ were detected via changes in Fluo-3 emission following application. A. Normalized fluorescence following application (arrow) of 10 μM Carbachol without (control) and with 10 or 100 μM Biperiden hydrochloride (#B-115), as indicated. B. Inhibition of 10 μM Carbachol effect, plotted against Biperiden hydrochloride concentrations.
- 1. Bonner, T.I. (1989) Trends. Neurosci. 12, 148.
- 2. Felder, C.C. (1995) FASEB. J. 9, 619.
- 3. Bolden, C. et al. (1992) J. Pharmacol. Exp. Ther. 260, 576.
- 4. Eltze, M. and Figala, V. (1988) Eur. J. Pharmacol. 158, 11.
- 5. Brocks, D.R. (1999) J. Pharm. Pharmaceut. Sci. 2, 39.
- 6. Sudo, Y. et al. (1999) Life Sci. 64, PL99.
-
Muscarinic acetylcholine receptors (mAChR) regulate a number of important basic physiologic functions including heart rate, motor and sensory control and more complex behaviors including arousal, memory, and learning. Loss of muscarinic receptor number or function has been implicated in the etiology of several neurological disorders including Alzheimer"s dementia, Down"s syndrome, and Parkinson"s disease. Five subtypes of muscarinic receptors (m1-m5) have been identified by molecular cloning1 and much has been learned about their distribution, pharmacology, and structure2.
Biperiden hydrochloride is a non-selective muscarinic receptor antagonist that displays selectivity for the M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M1, M4, M3, M2 and M5 receptors respectively)3-4. It is antiparkinsonian5 and therefore used for the adjunctive treatment of all forms of Parkinson"s disease (postencephalitic, idiopathic, and arteriosclerotic), also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy6.
Biperiden hydrochloride (#B-115) is a highly pure, synthetic, and biologically active compound.
