- Lc laboratories|阿西替尼, 游离碱
- 重磅!珀金埃尔默3.83亿美元收购Horizon Discovery_资讯中心_
- 仪表网仪表展览网,仪器仪表交易信息门户行业网站、资讯平台!
- Development and characterization of a novel antiOX40 antibody fo...
- Discovery Antibodies_代理
- lifesensors 特约代理
- 生物医药的前沿进展与市场趋势,看各位大咖怎么谈
- 纪录片频道 腾讯视频 QQ
- 第十届抗体药物及新药研发高峰会总日程——EBC2020|药物|...
- HBV RNA检测技术盘点:RTqPCR VS RNA捕获探针法|rna|hbv|pcr_网易订阅
- 柯云路记录的《生命科学探索孙储琳1》
- PWR0 600 50R/J Metallux
Lyophilized Powder This product is freeze dried. All water molecules have been removed.
Bioassay Tested Every lot is tried & tested in a relevant biological assay.
Our Bioassay
-
- Liao, C.F. et al. (1989) J. Biol. Chem. 264, 7328.
- Lazareno, S. et al. (1990) Br. J. Pharmacol. 109, 1120.
- Hernandez, M. et al. (1993) Br. J. Pharmacol. 110, 1413.
-
Alomone Labs Tropicamide inhibits carbachol’s effect on M1 mAChR expressed in C6 cells.Cells were loaded with Fluo-3 AM and changes in intracellular Ca2+ were detected via changes in Fluo-3 emission. A. Normalized fluorescence before and after application (at 20 seconds, see arrow) of 10 μM Carbachol following a 20 min incubation with 0-100 μM Tropicamide (#T-120) (as indicated). B. Inhibition (as percent of control) of 10 µM Carbachol evoked Ca2+ rise, plotted against Tropicamide concentrations.
- 1. Bonner, T.I. et al. (1989) Trends. Neurosci. 12, 148.
- 2. Felder, C.C. et al. (1995) FASEB. J. 9, 619.
- 3. Bonner, T.I. et al. (1987) Science 237, 527.
- 4. Peralta, E.G. et al. (1987) EMBO J. 6, 3923.
- 5. Bonner, T.I. et al. (1988) Neuron 1, 403.
- 6. Liao, C.F. et al. (1989) J. Biol. Chem. 264, 7328.
- 7. Liao, C.F. et al. (1989) J. Biol. Chem. 264, 7328.
- 8. Lazareno, S. et al. (1990) Br. J. Pharmacol. 109, 1120.
- 9. Hernandez, M. et al. (1993) Br. J. Pharmacol. 110, 1413.
- 10. Manny, R.E. et al. (2001) Invest. Ophtalmol. Vis. Sci. 42, 1728.
-
Muscarinic acetylcholine receptors (mAChR) regulate a number of important basic physiologic functions including heart rate, motor and sensory control and more complex behaviors including arousal, memory, and learning. Loss of muscarinic receptor number or function has been implicated in the etiology of several neurological disorders including Alzheimer"s dementia, Down"s syndrome and Parkinson"s disease.
Five subtypes of muscarinic receptors (m1-m5) have been identified by molecular cloning1 and much has been learned about their distribution, pharmacology, and structure2-6.
Tropicamide is a muscarinic receptor antagonist, which shows a 3 fold selectivity for m47-8. Its effect has a pIC50 of ~7.5 for porcine intravesical ureter contraction9.
Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle) when applied as eye drops. It is also an effective cycloplegic agent in myopic children10.
Tropicamide (#T-120) is a highly pure, synthetic, and biologically active compound.
