发现抗体/盐酸塔利哌索/5 mg/B-140-5 mg

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¥4940.00
货号:B-140-5mg
浏览量:109
品牌:Discovery
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商品描述
Cat#:ABR-031
AlternativeNameG-proteincoupledbileacidreceptor1,M-BAR,GPR131,BG37
  • LyophilizedPowder
  • AntigenIncl.
  • Type:Polyclonal
    Host:Rabbit
    Reactivity:m,r
    Mayalsoworkin:h*
      • Peptide(C)GDQRYTAPWRTAAQR,correspondingtoaminoacidresidues282-296ofratGPBAR1(Accession Q80T02).Intracellular,C-terminus.
        Anti-TGR5 (GPBAR1) Antibody
    Accession(Uniprot)NumberQ80T02
    GeneID7434
    PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.
    HomologyMouse-identical;human-14/15aminoacidresiduesidentical.
    RRIDAB_2340892.
    PurityAffinitypurifiedonimmobilizedantigen.
    FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN3.
    IsotypeRabbitIgG.
    StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.
    Reconstitution25µl,50µlor0.2mldoubledistilledwater(DDW),dependingonthesamplesize.
    Antibodyconcentrationafterreconstitution0.8mg/ml.
    StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°Cforupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000xg5min).
    NegativecontrolantigenstoragebeforereconstitutionLyophilizedpowdercanbestoredintactatroomtemperaturefor2weeks.Forlongerperiods,itshouldbestoredat-20°C.
    Negativecontrolantigenreconstitution100µldoubledistilledwater(DDW).
    Negativecontrolantigenstorageafterreconstitution-20°C.
    PreadsorptionControl2µgpeptideper1µgantibody.
    StandardqualitycontrolofeachlotWesternblotanalysis.
    Applications:wb
    Mayalsoworkin:ic*,ifc*,ih*,ip*
      • Anti-TGR5 (GPBAR1) Antibody
        Westernblotanalysisofratbrain(lanes1and4),mouseliver(lanes2and5)andratspleen(lanes3and6) lysates:
        1-3. Anti-TGR5(GPBAR1)Antibody (#ABR-031),(1:200).
        4-6.Anti-TGR5(GPBAR1)Antibody,preincubatedwiththenegativecontrolantigen.
    References
    • 1.Duboca,H.etal.(2014)Dig.LiverDis.46,302.
    • 2.Hov,J.R.etal.(2010)PLoSONE5,e12403.
    • 3.Kawamata,Y.etal.(2003)J.Biol.Chem.278,9435.
    • 4.Chen,X.andDing,H.(2011)Exp.DiabetesRes.2011,853501.
    • 5.Pols,T.W.etal.(2011)J.Hepatol.54,1263.
      • BileacidsareendogenousligandsforTGR5,a G-proteincoupledreceptor.Bileacidsareimportantamphipathicbiomoleculeswhichcanhelpabsorptionofdietarylipidsandfat-solublevitaminsintheintestine.TheTGR5receptoristhefirstknownG-proteincoupledreceptorspecificforbileacids1.

        ThecodingsequenceoftheTGR5genecontains993basepairs,encodingaproteinof330aminoacids.Thereceptorcomprisesseventransmembranehelices,threeextracellularloopscontributingtoligandbinding,andthreeintracellularloopsinvolvedinmediatingthesignaltodownstreamsignalingmolecules2.

        TGR5geneexpressioniswidelydistributed,includingendocrineglands,ADIpocytes,muscles,immuneorgans,spinalcord,andtheentericnervoussystem3.

        AnimalstudiessuggestthatTGR5activationinfluencesenergyproductionandtherebymaybeinvolvedinobesityanddiabetes.TGR5activationalsoinfluencesintestinalmotility.TGR5isnowrecognizedasapotentialtargetforthetreatmentofmetabolicdisorders,suchastype2diabetes1.Inaddition,theABIlityofTGR5tolowerthelevelsofproinflammatorycytokinesinmonocyteshasopenednewinsightsintothemodulatoryroleofbileacidsinpathologywhereinflammatoryprocessesplayacentralrole,includingcolitisandatheromadevelopment4,5.

    Applicationkey:

    CBE-Cell-basedELISA,FC-Flowcytometry,ICC-Immunocytochemistry,IE-IndirectELISA,IF-Immunofluorescence,IFC-Indirectflowcytometry,IHC-Immunohistochemistry,IP-Immunoprecipitation,LCI-Livecellimaging,N-Neutralization,WB-Westernblot

    Speciesreactivitykey:

    H-Human,M-Mouse,R-Rat
    receivea25µlfreetrialsample!
    Lastupdate:19/08/2019

    AlomoneLabsispleasedtoofferahighlyspecificantibodydirectedagainstanepitopetheratG-proteincoupledbileacidreceptor1.Anti-TGR5(GPBAR1)Antibody(#ABR-031)canbeusedinwesternblotanalysis.IthasbeendesignedtorecognizeTGR5frommouse,ratandhumansamples.

    Forresearchpurposesonly,notforhumanuse
    Discovery®抗体是Cambridge Research Biochemicals的目录抗体业务。 CRB是全球第二大最古老的肽公司,也是抗体研究市场的先驱,目前正以Discovery®Antibodies的名义建立一系列新验证的靶标抗体。 Discovery®抗体将专注于研究用抗体(早期药物“发现”),并将补充我们非常成功且长期存在的定制抗体业务(www.crbdiscovery.com)。我们已经以新颖,复杂,稀有和翻译后修饰的特异性抗体而闻名,这些受追捧的靶标将出现在我们的Discovery®Antibody目录范围内。  我们于2017年2月,在发现肽之后一年,并且在詹姆斯·库克船长(他当时最伟大的探险家)于1776年从英国出发,乘坐“ HMS发现”号开始租用新水域和“发现全球各地的新土地。因此,“发现”这个名称似乎适合东北制造商–詹姆斯·库克的故乡。 在1700年代后期对全球新发现土地的追求与医学研究的新“发现”以及2000年人类基因组图谱的发现之间,还有其他相似之处。  有关更多详细信息,请参见有关Discovery®抗体发布的新闻稿。   Cambridge Research Biochemicals  (www.crbdiscovery.com)成立于1980年,是英国领先的定制肽和抗体工具的独立生产商,为全球制药,生命科学和学术领域的研究人员提供产品。其产品的主要应用是定制的实验室规模试剂,用于早期药物发现中的主要研究证据,并支持临床研究中的生物标志物计划。该公司生产各种口味的肽,从简单到修饰,稳定和放射性标记,再到从毫克到克到最高纯度的染料标记。此外,CRB是产生高度特异性和靶向抗体(多克隆抗体和单克隆抗体)的公认专家。荧光染料标记也是重点。自1994年以来,该公司于2016年启动了其首个目录业务DISCOVERY®。
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