- Lc laboratories|阿西替尼, 游离碱
- 重磅!珀金埃尔默3.83亿美元收购Horizon Discovery_资讯中心_
- 仪表网仪表展览网,仪器仪表交易信息门户行业网站、资讯平台!
- Development and characterization of a novel antiOX40 antibody fo...
- Discovery Antibodies_代理
- lifesensors 特约代理
- 生物医药的前沿进展与市场趋势,看各位大咖怎么谈
- 纪录片频道 腾讯视频 QQ
- 第十届抗体药物及新药研发高峰会总日程——EBC2020|药物|...
- HBV RNA检测技术盘点:RTqPCR VS RNA捕获探针法|rna|hbv|pcr_网易订阅
- 柯云路记录的《生命科学探索孙储琳1》
- PWR0 600 50R/J Metallux
LyophilizedPowderThisproductisfreezedried.Allwatermoleculeshavebeenremoved.
- Peptide(CD)TINGTWEGDELGYK,correspondingtoaminoacidresidues11-24ofratP2RY2(AccessionP41232).Extracellular,C-terminus.

CellsurfacedetectionofP2RY2inliveintactmouseJ774macrophagecells:___ Cells.
___ Cells+rabbitIgGisotypecontrol-FITC.
___ Cells+Anti-P2Y2Receptor(extracellular)-FITCAntibody(#APR-102-F),(2.5µg).
CellsurfacedetectionofP2RY2inliveintacthumanTHP-1monocyticleukemiacells:___ Cells.
___ Cells+rabbitIgGisotypecontrol-FITC.
___ Cells+Anti-P2Y2Receptor(extracellular)-FITCAntibody(#APR-102-F),(5µg).
- 1.Wang,L.etal.(2002)J.Cardiovas.Pharmacol.40,841.
- 2.Queiroz,G.etal.(2003)J.Pharmacol.Exp.Ther.307,809.
- 3.Ralevic,V.andBurnstock,G.(1998)Pharmacol.Rev.50,413.
- 4.Abbracchio,M.P.etal.(2003)TrendsPharmacol.Sci.24,52.
- 5.DiVirgilio,F.etal.(2001)Blood97,587.
- 6.Yerxa,B.R.etal.(2002)J.Pharmacol.Exp.Ther.302,871.
P2Yreceptors belongtotheG-proteincoupledreceptorsuperfamily.P2Yreceptorsmediatetheactionsoftheextracellularnucleotides(ATP,ADP,UTPandUDP)andregulateseveralphysiologicalresponses,amongthem,cardiacfunction,plateletaggregationandSMCproliferation1.
ThemammalianP2Yfamilycurrentlyincludeseightfunctionalreceptors; P2Y1,P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13,andtheUDP-glucosereceptor,nowrenamed P2Y142-4.
TheP2Y2receptorisabundantlyexpressedintheapicalmembranesofseveralepithelialtissuesincludingairway5.IthasbecomealeADIngtargetforthetreatmentofcysticfibrosis.ActivationofP2RY2increasesCl- effluxandmucociliaryclearance,effectsthatmightrelievesymptomsofcysticfibrosis.P2Y2agoNISTtherapyistestedinanattempttobypassthedysfunctioningCFTRchannel.SeveralP2Y2receptoragonists, especiallyINS37217,beingevaluatedaspossIBLetargetsforthetreatmentofcysticfibrosis6.
Anti-P2Y2Receptor(extracellular)Antibody (#APR-102)isahighlyspecificantibodydirectedagainstanepitopeoftheratprotein.Theantibodycanbeusedinwesternblot,indirectlivecellflowcytometry,andimmunohistochemistryapplications.IthasbeendesignedtorecognizeP2RY2fromrat,mouse,andhumansamples.
Anti-P2Y2Receptor(extracellular)–FITCAntibody (#APR-102-F)isdirectlyconjugatedtofluoresceinisothiocyanate(FITC).Thislabeledantibody canbeusedinimmunofluorescentapplicationssuchasdirectflowcytometryusinglivecells.


