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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Lyophilized Powder Lyophilized Powder
This product is freeze dried. All water molecules have been removed.
Bioassay Tested Bioassay Tested
Every lot is tried & tested in a relevant biological assay.
Our Bioassay
Source Synthetic
MW: 356.3
Purity: >98% (HPLC)
Form Lyophilized powder.
Effective concentration 50 nM - 5 µM.
Chemical name (4S)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester.
Molecular formula C16H15 F3N2O4.
CAS No.: 98625-26-4.
Activity (S)(-)-Bay K8644 is an L-type Ca2+-channel activator. It displays vasoconstrictive effects in vivo1.
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- Franckowiak, G. et al. (1985) Eur. J. Pharmacol. 114, 223.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
-
Alomone Labs (S)(-)-Bay K8644 increases L-type CaV channel currents heterologously expressed in Xenopus oocytes.A. Time course of CaV1.2 (co-expressed with α2δ1 and β1 auxiliary subunits) peak current amplitude, elicited by 100 ms voltage ramp from holding potential of -100 mV to +50 mV, delivered every 10 seconds. Application of 0.1 and 1 µM (S)(-)-Bay K8644 (#B-351) increases the CaV1.2 current (indicated by the horizontal bar). B. Representative current traces before and during application of 0.1 and 1 µM (S)(-)-Bay K8644 as indicated.
References - Scientific background
- 1. Hadley, R.W. and Hume, J.R. (1988) Circ. Res. 62, 97.
- 2. Wei, X.Y. et al. (1986) J. Pharmacol. Exp. Ther. 239, 144.
- (S)(-)-Bay K8644 is an L-type Ca2+-channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo. It is an enantiomer of (±)-Bay K8644. (S)(-)-Bay K8644 is a dihydropyridine that can, among other effects, constrict blood vessels and increase the force of contraction of the heart. The drug is thought to increase the entry of Ca2+ into cells by increasing the open-state probability of Ca2+ channels, either by prolonging the duration of individual openings or by increasing the number of openings. It was noted in early experiments with Bay K8644 that the dose-response curve is biphasic1. The action of (S)(-)-Bay K8644 was studied in rat tail artery and guinea pig ileal longitudinal smooth muscle using pharmacologic and radioligand binding assays. It induced concentration-dependent contractions in both smooth muscle preparations with EC50 values of 1.98-11 nM. With increasing concentrations, (S)(-)-Bay K8644 relaxed the tissue with IC50 values of 0.53-2.60 μM2.
Target L-type Ca2+ channels
Lyophilized Powder
Click here to receive a 1 mg free trial sample!
Last update: 24/09/2019
(S)(-)-Bay K8644 (#B-351) is a highly pure, synthetic, and biologically active compound.
For research purposes only, not for human use
Discovery®抗体是Cambridge Research Biochemicals的目录抗体业务。 CRB是全球第二大最古老的肽公司，也是抗体研究市场的先驱，目前正以Discovery®Antibodies的名义建立一系列新验证的靶标抗体。 Discovery®抗体将专注于研究用抗体（早期药物“发现”），并将补充我们非常成功且长期存在的定制抗体业务（www.crbdiscovery.com）。我们已经以新颖，复杂，稀有和翻译后修饰的特异性抗体而闻名，这些受追捧的靶标将出现在我们的Discovery®Antibody目录范围内。 我们于2017年2月，在发现肽之后一年，并且在詹姆斯·库克船长（他当时最伟大的探险家）于1776年从英国出发，乘坐“ HMS发现”号开始租用新水域和“发现全球各地的新土地。因此，“发现”这个名称似乎适合东北制造商–詹姆斯·库克的故乡。 在1700年代后期对全球新发现土地的追求与医学研究的新“发现”以及2000年人类基因组图谱的发现之间，还有其他相似之处。 有关更多详细信息，请参见有关Discovery®抗体发布的新闻稿。 Cambridge Research Biochemicals （www.crbdiscovery.com）成立于1980年，是英国领先的定制肽和抗体工具的独立生产商，为全球制药，生命科学和学术领域的研究人员提供产品。其产品的主要应用是定制的实验室规模试剂，用于早期药物发现中的主要研究证据，并支持临床研究中的生物标志物计划。该公司生产各种口味的肽，从简单到修饰，稳定和放射性标记，再到从毫克到克到最高纯度的染料标记。此外，CRB是产生高度特异性和靶向抗体（多克隆抗体和单克隆抗体）的公认专家。荧光染料标记也是重点。自1994年以来，该公司于2016年启动了其首个目录业务DISCOVERY®。
