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LyophilizedPowderThisproductisfreezedried.Allwatermoleculeshavebeenremoved.
AntigenIncl.ThisantibodyisshippedwithitsantigenFREEofcharge!
- Peptide(C)KIRKNTWASHSSK,correspondingtoaminoacidresidues212-224oftheratAngiotensin-(1-7)Masreceptor(AccessionP12526).3rd intracellular loop.

Westernblotanalysisofratbrainlysate(lanes1and3)andmousebrainmembranes(lanes2and4):1,2.Guineapig Anti-Angiotensin-(1-7)MasReceptor Antibody(#AGP-099),(1:600).
3,4.GuineapigAnti-Angiotensin-(1-7)MasReceptorAntibody,preincubatedwiththenegativecontrolantigen.
- 1.Santos,R.A.etal.(2003)Proc.Natl.Acad.Sci.U.S.A.100,8258.
- 2.Alenina,N.etal.(2008)Exp.Physiol.93,528.
- 3.Santos,R.A.etal.(2008)Exp.Physiol.93,519.
TheAngiotensin-(1-7)MasreceptoristherecentlyidentifiedreceptoroftheBIOLOGicallyactiveheptapeptideangiotensin-(1-7).1
Angiotensin(Ang)-(1-7)isametaboliteofthewellknownpeptidehormoneAngiotensin(Ang)II,akeycomponentoftherenin-angiotensinsystem(RAS)thathasacentralroleincardiovascularhomeostasis.
ConsiderablyinterestinAng-(1-7)anditsreceptorarousedinthelastfewyearssinceitbecameapparentthatitcancounterbalancemostofAngIIeffects.ThusAng-(1-7)hasvasodilatorandhypotensiveeffectsaswellasantiarrhythmicandcardioprotectiveroles.2,3
TheAng-(1-7)Masreceptorbelongstothe7-transmembranedomain,Gprotein-coupledreceptor(GPCR)superfamilyandwasoriginallydescribedasaprotooncogene.
SignalingviatheAng-(1-7)Masreceptorisstillpoorlyelucidatedhowever,evidenceindicatesthatthereceptoriscoupledtoaGq/11 proteinthatactivatesphospholipaseC(PLC).2,3
TheAng-(1-7)Masreceptorisexpressedinseveralorgansincludingheart,kidney,bloodvessels,testisandbrain.StudieswithAng-(1-7)Masreceptorknockoutmicehavedemonstratedthekeyroleofthisreceptorincardiovascularregulationaswellasintheregulationoflearningandmemory.2
AlomoneLabsispleasedtoofferahighlyspecificantibodydirectedagainstanepitopeoftheratprotein.GuineapigAnti-Angiotensin-(1-7)MasReceptorAntibody(#AGP-099)raisedinguineapigcanbeusedinwesternblotanalysis.IthasbeendesignedtorecognizeAng-(1-7)Masreceptorfromrat,mouseandhumansamples.TheantigenusedtoimmunizeguineapigsisthesameasAnti-Angiotensin-(1-7)MasReceptorAntibody(#AAR-013)raisedinrabbit.Ourlineofguineapigantibodiesenablesmoreflexibilitywithourproductssuchasimmuno-colocalizationstudies,immunoprecipitation,etc.


