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- Nagarajan,N. etal. (2001) Neuropharmacology 41, 650.
- 1.Arai,A.andLynch,G. (1998) BrainRes. 799, 235.
- 2.Arai,A.C.andKessler,M. (2007) Curr.DrugTargets 8, 583.
- 3.Nagarajan,N. etal. (2001) Neuropharmacology 41, 650.
TheAMPAkinefamiliesofdrugsarepositiveallostericmodulatorsofAMPAreceptorsinthemammalianbrain.Thesecompoundsfacilitatelearningandmemoryinbothhumansandanimals.PositivemodulationofAMPAreceptorsbyAMPAkinescanimprovechannelfunctionbyincreasingreceptorsensitivitytoendogenousligandsandspecificagonists1.
TheAMPAkine1-(quinoxalin-6-ylcarbonyl)-piperidine(CX546)isabrain-penetratingcompound,whichfacilitatesAMPAreceptor-mediatedtransmission.CX546hasanEC50inahippocampalslicepreparationof150μMasmeasuredbypatchclampinculturedhippocampalneurons.TheactionofCX546onAMPAreceptortransmissionresultsinmemoryenhancement,whichhasbeendemonstratedinrodents,primates,andhumans2.
RecentfindingsnowindicatethatCX546-mediatedAMPAreceptorenhancementstrengthensneuronalsurvivalsignaling,leADIngtoconcomitantreductioninhippocampaldamage3.
CX546wasresearchedasatreatmentforAlzheimer"sdiseaseunderthebrandnameAmpalex.
CX546(#C-210) isahighlypure,synthetic,andbiologicallyactivecompound.




