Description:
ChromogenixCoamatic®FactorVIIIisachromogenicassaykitforthephotometricdeterminationoffactorVIIIactivityinplasma,suchaswhenidentifyingfactorVIIIdeficiencyormonitoringpatientsonreplacementtherapyaswellasforpotencyestimationofFVIIIconcentrates.This FactorVIIItestkitfulfillstherequirementsoftheEuropeanPharmacopoeiaforfactorVIIIconcentratetesting.Co-lyophilizationofreagentsforconvenienthandling.Reliabletoolforhemophiliaclassification.Nointerferencefromheparinlevelsupto1.5IU/ml.TheFactorVIIIkithastwomeasuringrangesplusvalidatedanddocumentedprotocolsforawiderangeofinstruments.
MeasurementPrinciple:
| FIXa,Ca2+,phospholipid | ||
| FactorX | → | FXa |
| FVIII | ||
| FXa | ||
| S-2765™ | → | Peptide+pNA |
Inthepresenceofcalciumionsandphospholipids,factorXisactivatedtofactorXabyfactorIXa.ThisactivationisgreatlystimulatedbyfactorVIIIwhichactsasacofactorinthisreaction.ByusingoptimalamountsofCa2+,phospholipidandfactorIXa,andanexcessoffactorX,therateofactivationoffactorXislinearlyrelatedtotheamountoffactorVIII.FactorXahydrolysesthechromogenicsubstrateS-2765™thusliberatingthechromophoricgroup,pNA.Thecolouristhenreadphotometricallyat405nm.ThegeneratedfactorXaandthustheintensityofcolourisproportionaltothefactorVIIIactivityinthesample.HydrolysisofS-2765™bythrombinformedispreventedbytheadditionofthesyntheticthrombininhibitorI-2581togetherwiththesubstrate.
Background:
PRECISE. SENSITIVE. ACCURATE. Coamatic®FactorVIIIforbetterhemophiliatesting.
TheChromogenixCoamatic®FactorVIIIassaykitprovidesreagentsandchromogenicmethodsfordeterminingfactorVIIIactivityinhumanplasmaandinfactorVIIIconcentrates.FactorVIIIisahighmolecularweightplasmaproteinwhichservesasacofactortofactorIXainitsactivationoffactorXtoXa.DeficiencyoffactorVIIIcausesaseverebleedingdisorder,hemophiliaA.TheseverityofthisbleedingdisorderisinverselyrelatedtothefactorVIIIconcentration.HemophiliaApatientsaregenerallyclassifiedaccordingtotheirfactorVIIIactivityintothreecategories:<0.01IU/mL=severe,0.01-0.04IU/mL=moderateand0.05-0.25IU/mL=mildhemophilia.
ReadmoreaboutchromogenicdeterminationofFactorVIII…
DiapharmaCOVID-19血清学您与COVID-19相关的血栓形成和纤溶产品的资源对于基于人群的COVID-19研究和基本的SARS-CoV-2研究项目，COVID-19血清学测试是一种有价值的研究工具。这包括疫苗试验，治疗药物试验，流行病学研究和患病率分析。免疫学，传染病和凝血领域的COVID-19研究也可能发现SARS-CoV-2抗体检测有益和适用。产品方法/应用打包使用 ？目录 ＃Restalyst RAPIT COVID-19 lgM / lgG测试试剂盒横向流动色谱免疫分析25个设备/套件RURUOCL0100NS0Restalyst COVID19-REAAD™抗SARS-CoV-2 IgG ELISAELISA法试剂盒/ 96孔RURUOCE0200NS2Restalyst COVID19N-REAAD™抗SARS-CoV-2核衣壳蛋白IgG ELISAELISA法试剂盒/ 96孔RURUOCE0100NP1Technozym®抗SARS-CoV-2 RBD IgG ELISA试剂盒ELISA法试剂盒/ 96孔RU5600100Technozym®抗SARS-CoV-2 NP IgG ELISA试剂盒ELISA法试剂盒/ 96孔RU5600200金标准诊断SARS-CoV-2 IgG ELISA测试试剂盒ELISA法套件/ 96孔新冠肺炎GSD01-1028金标准诊断SARS-CoV-2 IgA ELISA检测试剂盒ELISA法套件/ 96孔新冠肺炎GSD01-1029
