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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/L189/3561/10/10 mg

Tocris/L189/3561/10/10 mg

价格
￥3180.00
货号：3561/10
浏览量：127
品牌：Tocris
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商品描述
Description:DNAligaseI,IIIandIVinhibitor
ChemicalName:6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

DNAligaseI,IIIandIVinhibitor(IC50valuesare5,9and5μMrespectively)thatblocksDNAbinding(Ki=5μMforDNAligaseI).Preferentiallyinhibitsstep2oftheligationreaction,andinhibitsbaseexcisionrepair(BER)andnon-homologousendjoining(NHEJ).SpecificallysensitizescancercellstoDNAdamageandincreasesthecytotoxicityofDNA-damagingagents.

TechnicalData

M.Wt246.29
FormulaC11H10N4OS
StorageStoreat-20°C
CASNumber64232-83-3
PubChemID824710
InChIKeySAKOXVNKDMWWLF-UHFFFAOYSA-N
SmilesS=C1NC(N)=C(/N=C/C2=CC=CC=C2)C(N1)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO24.63100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight246.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM4.06mL20.3mL40.6mL
5mM0.81mL4.06mL8.12mL
10mM0.41mL2.03mL4.06mL
50mM0.08mL0.41mL0.81mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet