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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/HLI 373/3503/10/10毫克

Tocris/HLI 373/3503/10/10毫克

价格
￥3100.00
货号：3503/10
浏览量：127
品牌：Tocris
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商品描述
Description:Hdm2inhibitor;activatesp53-dependenttranscription
ChemicalName:5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dionedihydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofHdm2ubiquitinligase(E3).BlocksHdm2-mediatedubiquitylationandproteasomaldegradationofp53;activatesp53-dependenttranscription.Inducesapoptosisinseveraltumorcelllinesthatexpresswild-typep53suchasLOX-IMVI,A549,HT1080andU2OS.

TechnicalData

M.Wt414.33
FormulaC18H23N5O2.2HCl
StorageDesiccateatRT
Purity≥99%(HPLC)
CASNumber502137-98-6
PubChemID72193867
InChIKeyWUEMKAQTAIRDOA-UHFFFAOYSA-N
SmilesCN2C1=CC=CC=C1C(NCCCN(C)C)=C3C2=NC(N(C)C3=O)=O.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO3.7810
water37.79100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight414.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.41mL12.07mL24.14mL
5mM0.48mL2.41mL4.83mL
10mM0.24mL1.21mL2.41mL
50mM0.05mL0.24mL0.48mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet