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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/GS 143/5636/50/50毫克

Tocris/GS 143/5636/50/50毫克

价格
￥13300.00
货号：5636/50
浏览量：127
品牌：Tocris
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商品描述
Description:β-TRCP1ligaseinhibitor
ChemicalName:4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoicacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

β-TrCP1ligaseinhibitor.InhibitsIκBαubiquitination(IC50=5.2μM)withoutaffectingproteasomeactivity.BlocksLPS-inducedexpressionofinflammatorycytokinesinhumanmyelomonocyticcells.Suppressesantigen-inducedNFκBexpression,inflammationandmucusproductioninairwaysofOVA-sensitizedmice.

CompoundLibraries

GS143isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt466.46
FormulaC28H19FN2O4
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber916232-21-8
PubChemID11963988
InChIKeyIZPMWFSVTDOCDI-QJOMJCCJSA-N
SmilesFC1=CC=CC=C1C2=CC=C(/C=C3C(CC4=CC=CC=C4)=NN(C5=CC=C(C(O)=O)C=C5)C3=O)O2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO46.65100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight466.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.14mL10.72mL21.44mL
5mM0.43mL2.14mL4.29mL
10mM0.21mL1.07mL2.14mL
50mM0.04mL0.21mL0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet