Tocris蚂蚁淘在线

PotentVEGFRinhibitor(IC₅₀valuesare37and77nMforVEGFR-2and-1,respectively).Inhibitsproliferation,migrationandsurvivalofHUVECsinvitroandinhibitsgrowth,vascularizationandmetastasisoftumorsexpressingVEGFRinmousemodels.AlsoinhibitsPDGFR-β,c-Kitandc-Fms.Potentaromataseinhibitor(IC₅₀=50nM).Orallyavailable.

CompoundLibraries

VatalanibsuccinateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	464.9
Formula	C₂₀H₁₅ClN₄.C₄H₆O₄
Storage	Storeat-20°C
Purity	≥99%(HPLC)
CASNumber	212142-18-2
PubChemID	151193
InChIKey	LLDWLPRYLVPDTG-UHFFFAOYSA-N
Smiles	ClC(C=C1)=CC=C1NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42.OC(CCC(O)=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	46.49	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight464.9.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.15mL	10.76mL	21.51mL
5mM	0.43mL	2.15mL	4.3mL
10mM	0.22mL	1.08mL	2.15mL
50mM	0.04mL	0.22mL	0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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Tocris/Vatalanib琥珀酸盐/5680/10/10 mg

BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

MolarityCalculator

ReconstitutionCalculator

DilutionCalculator

ProductDatasheets