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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/GNF 5837/4559/10/10毫克

Tocris/GNF 5837/4559/10/10毫克

价格
￥4900.00
货号：4559/10
浏览量：127
品牌：Tocris
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商品描述
Description:PotentTrkinhibitor;inhibitsTrkA,TrkBandTrkC
ChemicalName:N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentpan-Trkinhibitor.DisplaysantiproliferativeeffectsincellularBa/F3assays(IC50valuesare7,9and11nMforcellscontainingthefusionproteinsTel-TrkC,Tel-TrkBandTel-TrkA,respectively).ExhibitsselectivityforTrkreceptorsoverarangeofkinases,withsomeactivityatPDGFRandc-Kit(IC50valuesare0.87and0.91μMrespectively).Orallybioavailable.

CompoundLibraries

GNF5837isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt535.49
FormulaC28H21F4N5O2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber1033769-28-6
PubChemID59397065
InChIKeyYYDUWLSETXNJJT-MTJSOVHGSA-N
SmilesO=C2NC1=CC(NC4=C(C)C=CC(NC(NC5=C(F)C=CC(C(F)(F)F)=C5)=O)=C4)=CC=C1/C2=C/C3=CC=CN3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO53.55100
ethanol5.3510

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight535.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.87mL9.34mL18.67mL
5mM0.37mL1.87mL3.73mL
10mM0.19mL0.93mL1.87mL
50mM0.04mL0.19mL0.37mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet