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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/Rac1抑制剂W56/2221/1/1 mg

Tocris/Rac1抑制剂W56/2221/1/1 mg

价格
￥4180.00
货号：2221/1
浏览量：127
品牌：Tocris
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商品描述
Description: Selective inhibitor of Rac1-GEF interaction
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1; selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1 and Tiam1. Control peptide available (Cat. No. 2222).

Technical Data

M. Wt 1671.93
Formula C74H117N19O23S
Sequence MVDGKPVNLGLWDTAG
Storage Desiccate at -20°C
CAS Number 1095179-01-3
PubChem ID 90488750
InChI Key IRORVMNZPUKWEX-YRMQSWGASA-N
Smiles [H]N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in PBS (pH 7.4)

Preparing Stock Solutions

The following data is based on the product molecular weight 1671.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.6 mL 2.99 mL 5.98 mL
5 mM 0.12 mL 0.6 mL 1.2 mL
10 mM 0.06 mL 0.3 mL 0.6 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

Product Datasheets

Certificate of Analysis / Product Datasheet
Safety Datasheet

References

References are publications that support the products' biological activity.

Gao et al (2001) Trp56 of Rac1 specifies interaction with a subset of guanine nucleotide exchange factors. J.Biol.Chem. 276 47530 PMID: 11595749

Keywords: Rac1 Inhibitor W56, supplier, Selective, inhibitors, inhibits, Rac1-GEF, interaction, GTPases, G, Proteins, Small, G, Proteins, (Small), GTPase, G, Proteins, (Small), Tocris Bioscience

我们的目的是通过提供全球范围内性能最高，最具创新性的研究试剂，使新的生命科学发现成为可能。 我们所做的 Tocris Bioscience是高性能生命科学试剂，肽和抗体的领先供应商，其客户几乎遍布全球所有主要的制药公司，大学和研究机构。该公司致力于通过提供最具创新性的高纯度产品来推动生命科学研究。我们的1,800多种试剂目录代表着独特的，新颖的，专有的和许可的研究工具，并且每年发送给全球50,000多名科学家。Tocris产品供科学家在癌症，心血管疾病，疼痛和感染等领域进行非临床研究时使用。