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BiologicalActivity
Inducescardiomyocytedifferentiationfromhumanembryonicstemcellsfollowingmesoderminductionat1μM.Inhibitscardiomyocytedifferentiationat5μM.PotentlyinhibitsCK1ε,p38α,andCK1δ(IC50valuesare6.4,6.7and6.8nMrespectively).
LicensingInformation
SoldunderagreementfromtheAgencyforScience,TechnologyandResearch(A*STAR),ETPL,andaffiliatesincludingtheBioprocessingTechnologyInstitute.
TechnicalData
| M.Wt | 351.32 |
| Formula | C20H12F3N3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 91691129 |
| InChIKey | TWPJJJZCYVFUOA-UHFFFAOYSA-N |
| Smiles | FC(C=C4)=CC=C4C(N=C(C3=C(F)C=CC=C3F)N2)=C2C1=CC=NC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.13 | 100 | |
| ethanol | 3.51 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight351.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.85mL | 14.23mL | 28.46mL |
| 5mM | 0.57mL | 2.85mL | 5.69mL |
| 10mM | 0.28mL | 1.42mL | 2.85mL |
| 50mM | 0.06mL | 0.28mL | 0.57mL |
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