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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/A 83-01/2939/50/50毫克

Tocris/A 83-01/2939/50/50毫克

价格
￥16500.00
货号：2939/50
浏览量：127
品牌：Tocris
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商品描述
Description:SelectiveinhibitorofTGF-βRI,ALK4andALK7
ChemicalName:3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentinhibitorofTGF-βtypeIreceptorALK5kinase,typeIactivin/nodalreceptorALK4andtypeInodalreceptorALK7(IC50valuesare12,45and7.5nMrespectively).BlocksphosphorylationofSmad2andinhibitsTGF-β-inducedepithelial-to-mesenchymaltransition.OnlyweaklyinhibitsALK-1,-2,-3,-6andMAPKactivity.MorepotentthanSB431542(Cat.No.1614).Inhibitsdifferentiationofratinducedpluripotentstemcells(riPSCs)andincreasesclonalexpansionefficiency.Helpsmaintainhomogeneityandlong-terminvitroself-renewalofhumaniPSCs.

CompoundLibraries

A83-01isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt421.52
FormulaC25H19N5S
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber909910-43-6
PubChemID16218924
InChIKeyHIJMSZGHKQPPJS-UHFFFAOYSA-N
SmilesS=C(NC5=CC=CC=C5)N(N=C3C4=NC(C)=CC=C4)C=C3C2=CC=NC1=CC=CC=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO21.0850

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight421.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.37mL11.86mL23.72mL
5mM0.47mL2.37mL4.74mL
10mM0.24mL1.19mL2.37mL
50mM0.05mL0.24mL0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet