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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/CCT 018159/2435/50/50毫克

Tocris/CCT 018159/2435/50/50毫克

价格
￥12580.00
货号：2435/50
浏览量：127
品牌：Tocris
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商品描述
Description:Hsp90inhibitor
ChemicalName:4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Novelinhibitorofheatshockprotein90(Hsp90)ATPaseactivity(IC50=5.7μM)thatdisplaysselectivityoverhumanHsp72andtopoisomeraseII.InhibitsproliferationofHCT116humancolontumorcellsandproducesupregulationofHsp70anddownregulationofc-Rafandcdk4.Moresolublethan17-AAG(Cat.No.1515)andisindependentofNQO1/DT-diaphoraseandP-glycoproteinexpression.

CompoundLibraries

CCT018159isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt352.39
FormulaC20H20N2O4
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber171009-07-7
PubChemID5327091
InChIKeyBBTMGPQSLSYPHE-ZHZULCJRSA-N
SmilesCCC1=C(O)C=C(O)C(=C1)C1=NNC(C)=C1C1=CC2=C(OCCO2)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO35.24100
ethanol35.24100
water1.765

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight352.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.84mL14.19mL28.38mL
5mM0.57mL2.84mL5.68mL
10mM0.28mL1.42mL2.84mL
50mM0.06mL0.28mL0.57mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet