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Biological Activity
Gene switch ligand. Transcription inducer for use in inducible gene expression systems. Does not cause significant changes in endogenous gene expression in HEK cells.
Technical Data
| M. Wt | 382.5 |
| Formula | C23H30N2O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 162326-49-0 |
| PubChem ID | 9929888 |
| InChI Key | QYYXITIZXRMPSZ-UHFFFAOYSA-N |
| Smiles | O=C(NN(C(C)(C)C)C(C2=CC(C)=CC(C)=C2)=O)C1=CC=CC(OC)=C1CC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.25 | 100 | |
| ethanol | 38.25 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 382.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.61 mL | 13.07 mL | 26.14 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.23 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.61 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Panguluri et al (2007) Effect of ecdysone receptor gene switch ligands on endogenous gene expression in 293 cells. FEBS Journal 274 5669 PMID: 17922837
Lapenna et al (2009) Semi-synthetic ecdysteroids as gene-switch actuators: synthesis, structure-activity relationships, and prospective ADME properties. ChemMedChem 4 55 PMID: 19065574
Keywords: RG 102240, supplier, RG102240, RheoSwitch, Ligands, inducible, expression, sytems, gene, switch, transcription, ecdysone, receptors, EcR, RSL1, Other, Transcription, Factors, DNA,, RNA, and, Protein, Synthesis, Other, Transcription, Factors, Tocris Bioscience
